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1. Deposition of Plaintiff Elizabeth Mekdeci at 56870, Mekdeci v. Merrell Nat'l Labs., Div. of Richardson-Merrell, Inc. M.D. Fla. filed Jan. 20, 1978 ; on file with the authors ; [hereinafter Mekdeci Deposition], aff'd 711 F.2d 1510 11th Cir. 1983 ; . Mrs. Mekdeci was the first plaintiff to bring an action against Merrell Dow claiming that the Bendectin she had taken in the first trimester of pregnancy had caused her child to be born with limb reduction. 2. 509 U.S. 579 1993 ; . Even without the strictures of Daubert, described infra in text accompanying notes 7 to 58, plaintiffs would confront difficulties in establishing a causal relationship between a toxic agent and resulting harm. Daubert has, however, raised the barrier to a plaintiff's ability to prove causation since it licenses courts to act as gatekeepers to exclude expert testimony that does not meet the criteria for admissibility set forth by the Supreme Court. Daubert, 509 U.S. at 58992, interpreted Federal Rule of Evidence 702, which was amended as of December 1, 2000 "in response to Daubert" and "the many cases applying Daubert." See Fed. R. Evid. 702 advisory committee's note, 28 U.S.C. App. at 893 2000 ; . The new language at the end of Rule 702 allows an expert to testify "if 1 ; the testimony is based upon sufficient facts or data, 2 ; the testimony is the product of reliable principles and methods, and 3 ; the witness has applied the principles and methods reliably to the facts of the case." Fed. R. Evid. 702. 3. See, e.g., Rider v. Sandoz Pharms. Corp., 295 F.3d 1194, 11971202 11th Cir. 2002 Glastetter v. Novartis Pharms. Corp., 252 F.3d 986, 98992 8th Cir. 2001 In re Meridia Prods. Liab. Litig., 328 F. Supp. 2d 791, 797809 N.D. Ohio 2004 Nelson v. Am. Home Prods. Corp., 92 F. Supp. 2d 954, 96673 W.D. Mo. 2000 Pick v. Am. Med. Sys., Inc., 958 F. Supp. 1151, 116478 E.D. La. 1997 Kelley v. Am. Heyer-Schulte Corp., 957 F. Supp. 873, 87783 W.D. Tex. 1997 Grimes v. Hoffman-La Rouche, Inc., 907 F. Supp. 33, 3739 D.N.H. 1995 Wade-Greaux v. Whitehall Labs., Inc., 874 F. Supp. 1441, 147685 D.V.I. 1994 ; . 4. See Symposium, Expert Admissibility: Keeping Gates, Goals and Promises, 34 Seton Hall L. Rev. 1 2003 ; . 5. Professor Berger has been a vocal critic of the tendency of courts applying Daubert to confuse the issue of admissibility of expert testimony with the sufficiency of the evidence to establish causation. See Brief of Amici Curiae Margaret A. Berger & Jerome P. Kassirer in Support of Plaintiff-Appellant at 2129, Rider v. Sandoz Pharms. Corp., 295 F.3d 1194 11th Cir. 2002 ; No. 6111965 BB and 01-CC Margaret A. Berger, Upsetting the Balance Between Adverse Interests: The Impact of the Supreme Court's Trilogy on Expert Testimony in Toxic Tort Litigation, 64 Law.
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Exhibit 4.12 UNDERWRITING AGREEMENT April 2, 2004 Draxis Health Inc. 6870 Goreway Drive Suite 200 Mississauga, Ontario L4V 1P1 Attention: Dear Sirs: Desjardins Securities Inc. and CIBC World Markets Inc. collectively, the "Underwriters" ; hereby severally offer to purchase from Draxis Health Inc. the "Company" ; , and the Company agrees to issue and sell to the Underwriters, 3, 053, 436 units of the Company "Units" ; upon the terms described in Schedule "A" hereto. Each Unit will consist of one common share a "Common Share" ; of the Company and one-half of one Common Share purchase warrant a "Warrant" ; . Each whole Warrant is transferable and will entitle the holder to purchase one Common Share a "Warrant Share" ; at an exercise price of .50 at any time on or before 5: 00 p.m. Toronto time ; on the date which is two years from the Closing Date as defined herein ; . The Warrants shall be created and issued pursuant to a warrant indenture the "Warrant Indenture" ; to be dated as of the Closing Date between Computershare Trust Company of Canada the "Warrant Agent" ; and the Company. The Underwriters shall have an option the "Option" ; , which Option may be exercised in the Underwriters' sole discretion and without obligation, to purchase up to an additional 458, 016 Units which, if subscribed for hereunder, shall be deemed to form part of the Units for the purposes hereof. The Option shall be exercisable by the Underwriters at any time up to 5: that date which is 30 days after the Closing Date as hereinafter defined ; by delivering written notice to the Company 24 hours prior to expiry of the Option, after which time the Option shall be void and of no further force and effect. ; . The Option shall be exercised by delivery of written notice to the Corporation prior to the expiry of the Option specifying the number of additional Units the "Additional Units" ; to be purchased. If the Option, or any portion thereof, is exercised, a separate closing the "Over-Allotment Closing" ; shall occur on the date specified by the Underwriters in such exercise notice and in any event, no later than 35 days following the Closing Date, and all applicable terms and conditions relating to the purchase of the Units on the Closing Date shall apply to the Over-Allotment Closing, as agreed to by respective counsel for the Underwriters and the Corporation. The offering of the Units which term shall include the Additional Units to be purchased in the event of the exercise of the Option ; by the Company is hereinafter referred to as the "Offering". Unless the context otherwise requires, all references to the "Units", "Common Shares", "Warrants", and "Warrant Shares" shall assume the exercise of the Option. In consideration of the Underwriters' services to be rendered in connection with the Offering, including assisting in preparing documentation relating to the Units including the Preliminary Prospectus and the Final Prospectus in each case as hereinafter defined ; , distributing the Units, directly and through other investment dealers and brokers, and performing administrative work in connection with the Offering, the Company agrees to pay the Underwriting Fee as hereinafter defined ; to the Underwriters. Martin Barkin, President and Chief Executive Officer, for example, meridia reductil.
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